Epilepsy: Mechanisms, Models, and Translational Perspectives by Jong Rho, Raman Sankar, Carl E. Stafstrom

By Jong Rho, Raman Sankar, Carl E. Stafstrom

Epilepsy has bothered humankind all through recorded heritage; but, it's only within the final half-century, that major development has been made in our uncomplicated realizing of the epileptic mind. Pivotal advances in drug improvement and surgical ideas, in addition to the emergence of leading edge methods corresponding to electric stimulation of the fearful method, have resulted in a considerable aid within the morbidity and mortality of sufferers with epilepsy. whilst, striking advancements in neuroscience have improved our knowing of mind constitution and function.

Epilepsy: Mechanisms, types, and Translational views accommodates new translational advances that carry epilepsy remedies from the laboratory bench to the bedside and again back. It brings jointly the paintings of greater than 70 of the field’s most beneficial and state-of-the-art researchers and clinicians. In 24 chapters, this terribly accomplished and present work:

Offers an outline of the fundamental anatomic and sensible substrates of seizure genesis and considers novel pathogenic techniques that experience either emerged and been proven experimentally
— Examines antiepileptic drug treatment, together with the newest on molecular targets
— seems on the nation of surgical remedies for epilepsy and discusses advances within the fields of structural and practical neuroimaging
— studies the range of nontraditional healing suggestions, equivalent to the ketogenic nutrition, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
— Investigates neuroendocrine, hormonal, and biobehavioral elements that effect seizure susceptibility—information that may be included into the layout of therapy algorithms on an individualized basis
— offers a glimpse of what destiny epilepsy treatments may perhaps seem like, from novel mechanisms of drug supply to gene and stem-cell treatments for epilepsy to seizure detection tools, to the final word target of ailment prevention.

The thought for this booklet used to be encouraged through the editors’ collective wish to advertise bridging of the so-called translational divide—that is, masking cutting edge therapy options in line with clinical ideas that experience but to be established conscientiously within the scientific surroundings, yet but could provide practitioners with new and promising methods towards epilepsy therapeutics.

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Extra info for Epilepsy: Mechanisms, Models, and Translational Perspectives

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