Clinical and Genetic Aspects of Epilepsy by Z. Afawi

By Z. Afawi

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J Neurosci Res 47:34-48. Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS (2009) The cortical innate immune response increases local neuronal excitability leading to seizures. Brain 132:2478-2486. Roy A, Fung YK, Liu X, Pahan K (2006) Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 281:14971-14980. Roy A, Jana A, Yatish K, Freidt MB, Fung YK, Martinson JA, Pahan K (2008) Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases.

The exact expression pattern within the CNS depends on the particular CYP and greatly varies between different brain cells. , 2008). The authors found mRNA expression of CYP2U1, CYP2S1, CYP2R1, CYP2B6, CYP2E1, CYP1A1, CYP2D6, CYP1B1, CYP2J2, CYP1A2, and CYP2C8. In another study, Gosh et al. , 2010). The cells that were used for this study originated from surgically resected brain specimens of drug-resistant epileptic patients, brain specimens resected from aneurism domes, commercially available human microvascular cerebral endothelial cells (used as control), and from human umbilical vein endothelial cells (used as control).

Roy A, Fung YK, Liu X, Pahan K (2006) Up-regulation of microglial CD11b expression by nitric oxide. J Biol Chem 281:14971-14980. Roy A, Jana A, Yatish K, Freidt MB, Fung YK, Martinson JA, Pahan K (2008) Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases. Free Radic Biol Med 45:686-699. Sayyah M, Najafabadi IT, Beheshti S, Majzoob S (2003) Lipopolysaccharide retards development of amygdala kindling but does not affect fully-kindled seizures in rats.

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