By Federico E. Micheli, Peter A. LeWitt
Chorea: reasons and Management offers a entire and well timed replace for the wide range of neurological stipulations, either inherited and purchased, which lead to this universal hyperkinetic circulation disorder.
This e-book describes intimately the newest scientific and etiological information about chorea. administration options, pathophysiology, and linked clinical and psychiatric difficulties linked to chorea also are addressed. the 19 chapters are contributed by way of internationally-recognized authors operating on the leading edge of study within the particular problems associated with chorea.
Chorea: reasons and Management is geared toward an viewers of neurologists, psychiatrists, neuropsychologists, experts in clinical genetics, medical and simple researchers in neurosciences, and generalist medical physicians with an curiosity in flow disorders.
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Extra resources for Chorea: Causes and Management
54. Bordelon YM. Clinical neurogenetics Huntington disease. Neurol Clin. 2013;31:1085–94. 55. MacMillan JC, Morrison PJ, Nervin NC, Shaw DJ, Harper PS, Quarrell OW, et al. Identification of an expanded CAG repeat in the Huntington’s disease gene (IT15) in a family reported to have benign hereditary chorea. J Med Genet. 1993;30:1012–3. 56. Britton JW, Uitti RJ, Ahlskog JE, Robinson RG, Kremer B, Hayden MR. Hereditary late-onset chorea without significant dementia: genetic evidence for substantial phenotypic variation in Huntington’s disease.
Atypical features previously reported include psychosis, dystonia, mental retardation, facial apraxia, epilepsy, hypospadias, pyramidal tract symptoms, and optic nerve glioma. Some individuals have been reported with intention tremor. The dystonic features associated with BHC are mild compared to dystonic syndromes. The abnormal postures tend to involve more frequently the upper than the lower half of the body, but severity in the lower limbs varies. Bradykinesia can occur, but it is considered as an atypical feature.
1981;56:616–21. 5. Schrag A, Quinn NP, Bhatia KP, Marsden CD. Benign hereditary chorea—entity or syndrome? Mov Disord. 2000;15:280–8. 26 C. A. González-Usigli 6. De Vries BBA, Arts WFM, Breedveld GJ, Hoogeboom JJM, Niermeijer MF, Heutink P. Benign hereditary chorea of early onset maps to chromosome 14q. Am J Hum Genet. 2000;66:136–42. 7. Willemsen MA, Breedveld GJ, Wouda M, Otten BJ, Yntema JL, Lammens M, et al. BrainThyroid-Lung syndrome: a patient with a severe multi-system disorder due to a de novo mutation in the thyroid transcription factor 1 gene.