Brain Lipids in Synaptic Function and Neurological Disease: by Jacques Fantini, Nouara Yahi

By Jacques Fantini, Nouara Yahi

Lipids are the main ample natural compounds present in the mind, accounting for as much as 50% of its dry weight. The mind lipidome contains numerous hundreds of thousands of targeted biochemical constructions whose expression could enormously fluctuate in line with age, gender, mind zone, telephone style, in addition to subcellular localization. In synaptic membranes, mind lipids in particular engage with neurotransmitter receptors and keep an eye on their job. furthermore, mind lipids play a key function within the new release and neurotoxicity of amyloidogenic proteins interested in the pathophysiology of neurological illnesses. the purpose of this e-book is to supply for the 1st time a complete evaluation of mind lipid buildings, and to provide an explanation for the jobs of those lipids in synaptic functionality, and in neurodegenerative illnesses, together with Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To finish the ebook, the authors current new rules which may force leading edge healing recommendations in line with the information of the position of lipids in mind disorders.

*Written to supply a "hands-on" technique for readers
*Biochemical constructions defined with molecular versions, and molecular mechanisms defined with uncomplicated drawings
*Step-by-step consultant to memorize and draw lipid structures
*Each bankruptcy encompasses a content material precis, up to date references for extra examine, and a key scan with an evidence of the procedure

Show description

Read or Download Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders PDF

Similar neuropsychology books

Cognition and the Brain: The Philosophy and Neuroscience Movement

This quantity presents an up-to-the-minute and entire review of the philosophy and neuroscience circulate, which applies the equipment of neuroscience to conventional philosophical difficulties and makes use of philosophical the way to remove darkness from concerns in neuroscience. on the middle of the stream is the conviction that easy questions about human cognition, lots of which were studied for millennia, should be responded in basic terms via a philosophically refined seize of neuroscience's insights into the processing of knowledge via the human mind.

Exposure Therapy for Anxiety: Principles and Practice

Publicity treatment is the best mental remedy for nervousness, but many clinicians lack self assurance of their skill to enforce it successfully whereas conserving consumers engaged. This crucial e-book offers instructions for accomplishing exposure-based interventions and overcoming universal roadblocks.

Cognitive Neuroscience: Research Directions In Cognitive Science: European perspectives, volume 4

This publication studies the growth made in Europe during the last decade within the box of Cognitive Neuroscience and issues out concepts for the longer term.

Performing Neurology: The Dramaturgy of Dr Jean-Martin Charcot

This article offers a research of Jean-Martin Charcot, a founding determine within the heritage of neurology as a self-discipline and a colleague of Sigmund Freud. It argues that Charcot’s diagnostic and pedagogic versions, explaining either how affliction is well-known and defined and the way to educate the act of neurological prognosis, might be thought of via a theatrical lens.

Extra info for Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders

Sample text

13 Lipid organization of the plasma membrane: a simplified model based on the theoretical shape of membrane lipids. The upper leaflet corresponds to the exofacial leaflet of the plasma membrane. Lipid raft domains (Lo phase) are enriched in cholesterol (chol) in both leaflets (exofacial and cytoplasmic). Sphingolipids (sphingomyelin SM and glycosphingolipids such as ganglioside GT1b) are located in the exofacial leaflet, whereas phosphatidylethanolamine (PE) is preferentially expressed in the cytoplasmic leaflet.

Add a methyl group (the left one is on C10, the right one on C13) and an isooctyl chain (on C17). 31. 31 Topology of cholesterol, a “bifacial” membrane lipid. (A) Structure of cholesterol with number- ing of the carbon atoms (left panel). If we follow the order of carbon numeration of the first cycle, we are moving in the counterclockwise direction, which defines the b face. The global shape of the cholesterol molecule, in the same orientation, is shown in the right panel. (B) Tube model of cholesterol showing its two topologically distinct faces: the smooth a face is devoid of substituents, whereas the opposite face (referred to as b) has several alkyl groups (two methyl groups and the isooctyl chain) that form a rough terrain.

3; 1874: 113. 9. Carter HE, Glick FJ, Norris WP, Phillips GE. Biochemistry of the sphingolipides III. Structure of sphingosine. J Biol Chem. 1947;170(1):285–294. 10. Shapiro D, Segal H, Flowers HM. The total synthesis of sphingosine. J Am Chem Soc. 1958;80(5):1194–1197. 11. Carter HE, Haines WJ, Ledyard WE, Norris WP. Biochemistry of the sphingolipides; preparation of sphingolipides from beef brain and spinal cord. J Biol Chem. 1947;169(1):77–82. 12. Pruett ST, Bushnev A, Hagedorn K, et al. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols.

Download PDF sample

Rated 4.87 of 5 – based on 10 votes