By Jacques Fantini, Nouara Yahi
Lipids are the main ample natural compounds present in the mind, accounting for as much as 50% of its dry weight. The mind lipidome contains numerous hundreds of thousands of targeted biochemical constructions whose expression could enormously fluctuate in line with age, gender, mind zone, telephone style, in addition to subcellular localization. In synaptic membranes, mind lipids in particular engage with neurotransmitter receptors and keep an eye on their job. furthermore, mind lipids play a key function within the new release and neurotoxicity of amyloidogenic proteins interested in the pathophysiology of neurological illnesses. the purpose of this e-book is to supply for the 1st time a complete evaluation of mind lipid buildings, and to provide an explanation for the jobs of those lipids in synaptic functionality, and in neurodegenerative illnesses, together with Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To finish the ebook, the authors current new rules which may force leading edge healing recommendations in line with the information of the position of lipids in mind disorders.
*Written to supply a "hands-on" technique for readers
*Biochemical constructions defined with molecular versions, and molecular mechanisms defined with uncomplicated drawings
*Step-by-step consultant to memorize and draw lipid structures
*Each bankruptcy encompasses a content material precis, up to date references for extra examine, and a key scan with an evidence of the procedure
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Extra info for Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders
13 Lipid organization of the plasma membrane: a simplified model based on the theoretical shape of membrane lipids. The upper leaflet corresponds to the exofacial leaflet of the plasma membrane. Lipid raft domains (Lo phase) are enriched in cholesterol (chol) in both leaflets (exofacial and cytoplasmic). Sphingolipids (sphingomyelin SM and glycosphingolipids such as ganglioside GT1b) are located in the exofacial leaflet, whereas phosphatidylethanolamine (PE) is preferentially expressed in the cytoplasmic leaflet.
Add a methyl group (the left one is on C10, the right one on C13) and an isooctyl chain (on C17). 31. 31 Topology of cholesterol, a “bifacial” membrane lipid. (A) Structure of cholesterol with number- ing of the carbon atoms (left panel). If we follow the order of carbon numeration of the first cycle, we are moving in the counterclockwise direction, which defines the b face. The global shape of the cholesterol molecule, in the same orientation, is shown in the right panel. (B) Tube model of cholesterol showing its two topologically distinct faces: the smooth a face is devoid of substituents, whereas the opposite face (referred to as b) has several alkyl groups (two methyl groups and the isooctyl chain) that form a rough terrain.
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