2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

This bestselling and prevalent source on pediatric antimicrobial remedy offers quick entry to trustworthy ideas for therapy of all infectious ailments in children.

For every one illness, the authors supply a statement to assist health and wellbeing care services choose the easiest of all antimicrobial offerings. The inquiring health care professional can instantly hyperlink to the facts for the advice within the booklet or cellular model. Drug descriptions disguise all antimicrobial brokers to be had this present day and comprise whole information regarding dosing regimens.

In reaction to transforming into issues approximately overuse of antibiotics, the e-book comprises guidance on whilst to not prescribe antimicrobials.

Key good points in nineteenth Edition!

- up to date information about the power and the extent of facts for all remedy concepts

- New bankruptcy on antibiotic treatment for overweight little ones

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- comprises therapy of parasitic infections and tropical drugs.

- up-to-date anti-infective drug directory, entire with formulations and dosages.

- Balanced info on security, efficacy and tolerability with facts on charges and availability of substances

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Extra resources for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Sample text

Palivizumab was not investigated to treat an active infection. Palivizumab may benefit immunocompromised children and those with cystic fibrosis, but Is not routinely recommended as benefits not well defined. 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 25 – S aureus16,75–77 Condition Therapy (evidence grade) See Table 5B for Neonatal Dosages Comments Pulmonary infections (cont) Sepsis and meningitis78,83,84 NOTE: Duration of therapy: 10 days for sepsis without a focus (AIII); minimum of 21 days for gram-negative meningitis (or at least 14 days after CSF is sterile) and 14–21 days for GBS meningitis and other gram-positive bacteria (AIII) There are no prospective, controlled studies on 5- or 7-day courses for mild or presumed sepsis.

During the past 2 years, clindamycin resistance in MRSA has increased to 40% in some areas, but remained stable at 5% in others. Please check your local susceptibility data for S aureus before using clindamycin for empiric therapy. For MSSA, oxacillin/nafcillin are considered equivalent agents. 39 – Newborns See Chapter 5. 35,36 – Gonococcal arthritis or tenosynovitis40,41 Ceftriaxone 50 mg/kg IV, IM q24h (BII); for 7 days PO cefixime 8 mg/kg/day as a single daily dose has not yet been studied in children, but is recommended as step-down therapy in adults, to complete a 7-day treatment course.

Antimicrobial Therapy According to Clinical Syndromes A. SKIN AND SOFT TISSUE INFECTIONS (cont) Empiric therapy: ceftazidime 150 mg/kg/day IV div q8h, or cefepime 150 mg/kg/day IV div q8h or cefotaxime 200 mg/kg/day IV div q6h AND clindamycin 40 mg/kg/day IV div q8h (BIII); OR meropenem 60 mg/kg/day IV div q8h; OR pip/tazo 400 mg/kg/day pip component IV div q6h (AIII) ADD vancomycin for suspect CA-MRSA, pending culture results (AIII) Group A streptococcal: penicillin G 200,000–250,000 U/kg/day div q6h AND clindamycin 40 mg/kg/day div q8h (AIII) Mixed aerobic/anaerobic/gram-negative: meropenem or pip/tazo AND clindamycin (AIII) Aggressive emergent wound debridement (AII) Add clindamycin to inhibit synthesis of toxins at the ribosomal level (AIII).

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